Organonitrogen Compounds
Medchemexpress LLC Glucosylceramide synthase-IN-2 | 2597958-02-4 | 98.62% | C22H20F3N3O4 | 1 ML
Glucosylceramide synthase-IN-2 is a potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS). It demonstrates IC50 values of 15 nM for human GCS and 190 nM for mouse GCS, exhibiting noncompetitive inhibition with C8-ceramide and UDP-glucose. This compound is applicable for research related to Gaucher's disease, showing no significant inhibitory activity against SERT or GCase in vitro. In vivo studies confirm good oral and brain exposure in mice, reducing GlcCer concentrations in plasma and cerebral cortex.
- Potent GCS inhibitor
- Brain-penetrant
- Orally active
- Noncompetitive inhibition type with C8-ceramide and UDP-glucose
- Useful for Gaucher's disease research
- Does not significantly inhibit SERT or GCase activity in vitro
- Shows good oral and brain exposure in vivo
Medchemexpress LLC Cymoxanil | 57966-95-7 | 99.6% | 500 MG
Cymoxanil is a fungicidal cyanooxime that targets plant diseases caused by fungi belonging to the Perenosporales. It affects growth, DNA, and RNA synthesis in Phytophthora.
- Targets fungal plant diseases belonging to Perenosporales
- Impacts growth, DNA, and RNA synthesis in Phytophthora
- Highly sensitive against colony growth and germ tube emergence of Phytophthora infestans sporangia and encysted zoospores (ED50: 0.5-1.5 μg/mL)
- Insignificant histopathological changes in treated rats at low doses
- Exhibits adverse signs and symptoms of toxicity at medium and high doses
- Hepatotoxicity and nephrotoxicity observed in rats at higher doses
Apexbio Technology LLC MILAMELINE HYDROCHLORIDE 10MG
MILAMELINE HYDROCHLORIDE 10MG APEXBIO TECHNOLOGIES
Medchemexpress LLC Cymoxanil | 57966-95-7 | 99.6% | 5 G
Cymoxanil is a fungicidal cyanooxime that targets plant diseases caused by fungi belonging to the Perenosporales. It works by affecting the growth, DNA, and RNA synthesis in Phytophthora.
- Fungicidal cyanooxime.
- Targets plant diseases caused by fungi belonging to the Perenosporales.
- Affects growth, DNA, and RNA synthesis in Phytophthora.
Aobchem 4-Fluoroacetophenone oxime | 95% | CAS 329-79-3 | C8H8FNO | 500mg
4-Fluoroacetophenone oxime | 95% | CAS 329-79-3 | C8H8FNO | 500mg
Aobchem 4-Fluoroacetophenone oxime | 95% | CAS 329-79-3 | C8H8FNO | 5g
4-Fluoroacetophenone oxime | 95% | CAS 329-79-3 | C8H8FNO | 5g
Aobchem Benzaldehyde 4-bromo- oxime | ≥95% | CAS 34158-73-1 | C7H6BrNO | 5g
Benzaldehyde 4-bromo- oxime | ≥95% | CAS 34158-73-1 | C7H6BrNO | 5g
Aobchem Benzaldehyde 4-bromo- oxime | ≥95% | CAS 34158-73-1 | C7H6BrNO | 1g
Benzaldehyde 4-bromo- oxime | ≥95% | CAS 34158-73-1 | C7H6BrNO | 1g
Aobchem (E)-3-fluorobenzaldehyde oxime | ≥95% | CAS 154238-36-5 | C7H6FNO | 5g
(E)-3-fluorobenzaldehyde oxime | ≥95% | CAS 154238-36-5 | C7H6FNO | 5g
Aobchem (E)-3-fluorobenzaldehyde oxime | ≥95% | CAS 154238-36-5 | C7H6FNO | 25g
(E)-3-fluorobenzaldehyde oxime | ≥95% | CAS 154238-36-5 | C7H6FNO | 25g
Aobchem (E)-4-bromobenzaldehyde oxime | 97% | CAS 40979-16-6 | C7H6BrNO | 500mg
(E)-4-bromobenzaldehyde oxime | 97% | CAS 40979-16-6 | C7H6BrNO | 500mg
Aobchem (E)-4-bromobenzaldehyde oxime | 97% | CAS 40979-16-6 | C7H6BrNO | 250mg
(E)-4-bromobenzaldehyde oxime | 97% | CAS 40979-16-6 | C7H6BrNO | 250mg
Aobchem Acetophenone 2 -ethoxy-3 -methoxy- | 95% | CAS 857566-10-0 | C11H14O3 | 250mg
Acetophenone 2 -ethoxy-3 -methoxy- | 95% | CAS 857566-10-0 | C11H14O3 | 250mg
eMolecules 502-49-8 | Cyclooctanone | Oakwood Chemical | MFCD00001754 | 126.199 | C8H14O | 97.000 | O=C1CCCCCCC1 | 10g | 537718032
Cyclooctanone | Oakwood Chemical | 502-49-8 | MFCD00001754 | 126.199 | C8H14O | 97.000 | O=C1CCCCCCC1 | 10g | 537718032
Apexbio Technology LLC Indirubin-3'-oxime 160807-49-8 5mg
Indirubin-3 -oxime (CAS 160807-49-8) is a derivative of indirubin investigated primarily as an inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 22 nM This compound also inhibits CDK5/p25 and CDK1/cyclin B with IC50 values of around 100 nM and 180 nM respectively while demonstrating weaker inhibitory activity against 5-lipoxygenase (IC50 7 8 10 M) Due to its modulation of multiple kinases involved in cell signaling Indirubin-3 -oxime is widely utilized in research on cellular signaling pathways and the molecular mechanisms underlying disease