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TRAIL Protein (TNFSF10) a member of the TNF superfamily is a type II transmembrane protein TRAIL Protein mainly interacts with TRAIL-R1 and TRAIL-R2 and induces apoptosis in tumor or infected cells TRAIL Protein also binds with DR4 DR5 and OPG TRAIL Protein can recruit FADD and further recruit and activates caspase-8 after binding to DR4 or DR5 Besides TRAIL may also trigger nonapoptotic signaling through activating pro-inflammatory pathways[1][2] TRAIL protein is mainly expressed on surface of immune cells such as cytotoxic T cells and natural killer (NK) cell[1] TRAIL/TNFSF10 Protein Human (HEK293 His-Flag) is a recombinant human TRAIL (G118-G281) with N-terminal His and Flag tag which is expressed in HEK293
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Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) is an active compound that inhibits toxoplasmic encephalitis, as well as protozoan and bacterial infections. It is intended for research use only.
Active compound for toxoplasmic encephalitis inhibition
Inhibits protozoan and bacterial infections
For research use only
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BAFF/TNFSF13B protein is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA forming a key ligand-receptor pathway together with TNFSF13/APRIL These interactions play a crucial role in stimulating B-cell and T-cell function and regulating humoral immunity BAFF/TNFSF13B Trimer Protein Human (HEK293 His-Flag) is the recombinant human-derived BAFF/TNFSF13B protein expressed by HEK293 with N-His N-Flag labeled tag
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Recombinant human APRIL/TNFSF13 trimer produced in HEK293 cells and supplied with a His-Flag tag; designed for in vitro receptor binding and functional studies related to B-cell biology and lymphatic malignancies.
Suitable for receptor binding assays and biochemical characterization.
Trimeric form mimics the native ligand assembly for functional studies.
HEK293 expression supports mammalian folding and glycosylation.
Affinity tags enable straightforward purification and detection.
Optimized for cell signaling and ligand-receptor interaction experiments.
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AITRL a type II transmembrane protein is a ligand for glucocorticoid-induced TNFR-related protein (GITR) When AITRL binds to GITR GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions GITR/AITRL interaction plays a role in the pathogenesis of tumor inflammation as well as autoimmune diseases[1] Besides AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1 ICAM-1)[2] AITRL/TNFSF18 Protein Human (Biotinylated HEK293 His-Flag) is a recombinant biotinylated human AITRL (Q72-S199) with N-terminal His and Flag tag which is expressed in HEK293
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Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) with mixed competitive and noncompetitive activity. It also exhibits anti-hypertensive activity and can attenuate sympathetic activity and blood pressure in spontaneously hypertensive animal models.
Target: nAChR (nicotinic-receptor)
Research areas: Apoptosis, cardiovascular disease, neurological disease
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Hexamethonium Bromide (CAS 55-97-0) is a bis-quaternary ammonium compound that acts as a selective antagonist of neuronal nicotinic acetylcholine receptors (nAChRs) located in autonomic ganglia By competitively inhibiting synaptic transmission at these receptors Hexamethonium Bromide effectively blocks ganglionic neurotransmission without significant effects on muscarinic receptors or neuromuscular junctions This property makes it a valuable tool in pharmacological studies investigating autonomic nervous system function and the physiological roles of ganglionic nAChRs in various experimental models
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